Adrenaline has an important role in the management of acute allergic reactions and can be life-saving in patients with anaphylaxis and anaphylactic shock. It is also used in advanced cardiac life support. Adrenaline has been used in the treatment of acute asthma but more selective drugs are available, and it has no role in the chronic management of asthma. It has been given by nebulisation in severe group. Adrenaline is used for a number of other indications including the control of minor bleeding from the skin and mucous membranes, in ophthalmology chiefly for the management of open-angle (simple) glaucoma, and also as an adjunct to local anaesthesia.